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doxycycline high fat diet  (Bio-Serv)

 
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    Bio-Serv doxycycline high fat diet
    (A–K) Control (Lrat-rtTA) and LAPNTG (Lrat-rtTA+TRE-Adipoq) mice were housed under thermoneutral conditions and fed HFD+DOX to induce liver fibrosis. (A) Experimental setup. (B) Adiponectin mRNA expression in HSCs after 2 weeks’ <t>doxycycline.</t> (C) Circulating adiponectin levels after 2 weeks’ doxycycline ( n = 5). (D) Body weight development. (E) OGTT after 8 weeks ( n = 5–8). (F–J) Liver mRNA expression of (F) Col1a1, (G) Col3a1, (H) Col4a4, (I) TGF-β, and (J) smooth muscle actin after 1 year under thermoneutral conditions. (K) Liver trichrome staining. Scale bar represents 100 μm. (L) Picrosirius red staining. Scale bar represents 100 μm. (M) Quantification of fibrotic area. (N–U) Control (MUP-uPA+Lrat-rTA) and MUPLAPNTG (MUP-uPA+Lrat-rtTA+TRE-Adipoq) mice were fed chow+DOX. (N) Experimental setup. (O–Q) Liver mRNA expression of (O) smooth muscle actin, (P) Col3a1, and (Q) Col4a4 after 20 weeks. (R) Liver trichrome staining after 20 weeks ( n = 10). (S) Picrosirius red staining. (T) Quantification of fibrotic area. (U) Liver tumors after 20 weeks’ HFD plus Dox600 ( n = 10). Data are displayed as mean ± SEM and analyzed by unpaired Student’s t test for all the figures: * p < 0.05, ** p < 0.01, *** p < 0.001.
    Doxycycline High Fat Diet, supplied by Bio-Serv, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/doxycycline+high+fat+diet/doxycycline+high+fat+diet/pmc11839304-101-0-8
    Average 90 stars, based on 1 article reviews
    doxycycline high fat diet - by Bioz Stars, 2026-09
    90/100 stars

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    1) Product Images from "The adiponectin-PPARγ axis in hepatic stellate cells regulates liver fibrosis"

    Article Title: The adiponectin-PPARγ axis in hepatic stellate cells regulates liver fibrosis

    Journal: Cell reports

    doi: 10.1016/j.celrep.2024.115165

    (A–K) Control (Lrat-rtTA) and LAPNTG (Lrat-rtTA+TRE-Adipoq) mice were housed under thermoneutral conditions and fed HFD+DOX to induce liver fibrosis. (A) Experimental setup. (B) Adiponectin mRNA expression in HSCs after 2 weeks’ doxycycline. (C) Circulating adiponectin levels after 2 weeks’ doxycycline ( n = 5). (D) Body weight development. (E) OGTT after 8 weeks ( n = 5–8). (F–J) Liver mRNA expression of (F) Col1a1, (G) Col3a1, (H) Col4a4, (I) TGF-β, and (J) smooth muscle actin after 1 year under thermoneutral conditions. (K) Liver trichrome staining. Scale bar represents 100 μm. (L) Picrosirius red staining. Scale bar represents 100 μm. (M) Quantification of fibrotic area. (N–U) Control (MUP-uPA+Lrat-rTA) and MUPLAPNTG (MUP-uPA+Lrat-rtTA+TRE-Adipoq) mice were fed chow+DOX. (N) Experimental setup. (O–Q) Liver mRNA expression of (O) smooth muscle actin, (P) Col3a1, and (Q) Col4a4 after 20 weeks. (R) Liver trichrome staining after 20 weeks ( n = 10). (S) Picrosirius red staining. (T) Quantification of fibrotic area. (U) Liver tumors after 20 weeks’ HFD plus Dox600 ( n = 10). Data are displayed as mean ± SEM and analyzed by unpaired Student’s t test for all the figures: * p < 0.05, ** p < 0.01, *** p < 0.001.
    Figure Legend Snippet: (A–K) Control (Lrat-rtTA) and LAPNTG (Lrat-rtTA+TRE-Adipoq) mice were housed under thermoneutral conditions and fed HFD+DOX to induce liver fibrosis. (A) Experimental setup. (B) Adiponectin mRNA expression in HSCs after 2 weeks’ doxycycline. (C) Circulating adiponectin levels after 2 weeks’ doxycycline ( n = 5). (D) Body weight development. (E) OGTT after 8 weeks ( n = 5–8). (F–J) Liver mRNA expression of (F) Col1a1, (G) Col3a1, (H) Col4a4, (I) TGF-β, and (J) smooth muscle actin after 1 year under thermoneutral conditions. (K) Liver trichrome staining. Scale bar represents 100 μm. (L) Picrosirius red staining. Scale bar represents 100 μm. (M) Quantification of fibrotic area. (N–U) Control (MUP-uPA+Lrat-rTA) and MUPLAPNTG (MUP-uPA+Lrat-rtTA+TRE-Adipoq) mice were fed chow+DOX. (N) Experimental setup. (O–Q) Liver mRNA expression of (O) smooth muscle actin, (P) Col3a1, and (Q) Col4a4 after 20 weeks. (R) Liver trichrome staining after 20 weeks ( n = 10). (S) Picrosirius red staining. (T) Quantification of fibrotic area. (U) Liver tumors after 20 weeks’ HFD plus Dox600 ( n = 10). Data are displayed as mean ± SEM and analyzed by unpaired Student’s t test for all the figures: * p < 0.05, ** p < 0.01, *** p < 0.001.

    Techniques Used: Control, Expressing, Staining


    Figure Legend Snippet:

    Techniques Used: Recombinant, Enzyme-linked Immunosorbent Assay, cDNA Synthesis, SYBR Green Assay, Generated, Software, Fluorescence, Microscopy



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    Image Search Results


    (A–K) Control (Lrat-rtTA) and LAPNTG (Lrat-rtTA+TRE-Adipoq) mice were housed under thermoneutral conditions and fed HFD+DOX to induce liver fibrosis. (A) Experimental setup. (B) Adiponectin mRNA expression in HSCs after 2 weeks’ doxycycline. (C) Circulating adiponectin levels after 2 weeks’ doxycycline ( n = 5). (D) Body weight development. (E) OGTT after 8 weeks ( n = 5–8). (F–J) Liver mRNA expression of (F) Col1a1, (G) Col3a1, (H) Col4a4, (I) TGF-β, and (J) smooth muscle actin after 1 year under thermoneutral conditions. (K) Liver trichrome staining. Scale bar represents 100 μm. (L) Picrosirius red staining. Scale bar represents 100 μm. (M) Quantification of fibrotic area. (N–U) Control (MUP-uPA+Lrat-rTA) and MUPLAPNTG (MUP-uPA+Lrat-rtTA+TRE-Adipoq) mice were fed chow+DOX. (N) Experimental setup. (O–Q) Liver mRNA expression of (O) smooth muscle actin, (P) Col3a1, and (Q) Col4a4 after 20 weeks. (R) Liver trichrome staining after 20 weeks ( n = 10). (S) Picrosirius red staining. (T) Quantification of fibrotic area. (U) Liver tumors after 20 weeks’ HFD plus Dox600 ( n = 10). Data are displayed as mean ± SEM and analyzed by unpaired Student’s t test for all the figures: * p < 0.05, ** p < 0.01, *** p < 0.001.

    Journal: Cell reports

    Article Title: The adiponectin-PPARγ axis in hepatic stellate cells regulates liver fibrosis

    doi: 10.1016/j.celrep.2024.115165

    Figure Lengend Snippet: (A–K) Control (Lrat-rtTA) and LAPNTG (Lrat-rtTA+TRE-Adipoq) mice were housed under thermoneutral conditions and fed HFD+DOX to induce liver fibrosis. (A) Experimental setup. (B) Adiponectin mRNA expression in HSCs after 2 weeks’ doxycycline. (C) Circulating adiponectin levels after 2 weeks’ doxycycline ( n = 5). (D) Body weight development. (E) OGTT after 8 weeks ( n = 5–8). (F–J) Liver mRNA expression of (F) Col1a1, (G) Col3a1, (H) Col4a4, (I) TGF-β, and (J) smooth muscle actin after 1 year under thermoneutral conditions. (K) Liver trichrome staining. Scale bar represents 100 μm. (L) Picrosirius red staining. Scale bar represents 100 μm. (M) Quantification of fibrotic area. (N–U) Control (MUP-uPA+Lrat-rTA) and MUPLAPNTG (MUP-uPA+Lrat-rtTA+TRE-Adipoq) mice were fed chow+DOX. (N) Experimental setup. (O–Q) Liver mRNA expression of (O) smooth muscle actin, (P) Col3a1, and (Q) Col4a4 after 20 weeks. (R) Liver trichrome staining after 20 weeks ( n = 10). (S) Picrosirius red staining. (T) Quantification of fibrotic area. (U) Liver tumors after 20 weeks’ HFD plus Dox600 ( n = 10). Data are displayed as mean ± SEM and analyzed by unpaired Student’s t test for all the figures: * p < 0.05, ** p < 0.01, *** p < 0.001.

    Article Snippet: Doxycycline High fat diet (600 mg/kg diet) , BioServ , N/A.

    Techniques: Control, Expressing, Staining

    Journal: Cell reports

    Article Title: The adiponectin-PPARγ axis in hepatic stellate cells regulates liver fibrosis

    doi: 10.1016/j.celrep.2024.115165

    Figure Lengend Snippet:

    Article Snippet: Doxycycline High fat diet (600 mg/kg diet) , BioServ , N/A.

    Techniques: Recombinant, Enzyme-linked Immunosorbent Assay, cDNA Synthesis, SYBR Green Assay, Generated, Software, Fluorescence, Microscopy